In the meantime, the Colts must replace his productivity.
Darrius Heyward-Bey, Oakland's first-round pick in 2008, and T.Y. Hilton, a second-year receiver who led all rookies in TD receptions (seven) and set a franchise rookie record with five 100-yard games last season, will both be asked to do more.
Tight end Coby Fleener, a second-round pick in 2012 who has played the past six seasons with Luck, is likely to play a bigger role in the offense, too.
On Monday, the Colts made it clear they expect another key cog from the Stanford class of 2012 to pitch in by promoting Griff Whalen from the practice squad to the active roster.
Whalen was an undrafted rookie who spent last season on injured reserve. He played in three games in September, caught two passes for 28 yards, then was cut and brought back to the practice squad Oct. 1.
"Very excited for Griff," Luck said. "It's a good chance for him. He's always been ready and ready to roll."
The Colts have to be ready to go, too.
They have no scheduled breaks between now and the Dec. 29 regular-season finale against Jacksonville and are about to face one of this season's most daunting stretches.
After visiting Houston this weekend, for a third straight prime-time game, they return home to face struggling St. Louis on Nov. 10 followed by yet another night game Nov. 14 at Tennessee.
Win all three and the Colts would extend their division lead, be 3-0 in division games — with all three wins on the road — and head into a well-deserved long weekend in control of the AFC South title chase.
The tough stretch starts Sunday against Houston, which has lost five straight and has gone from preseason Super Bowl contender to major disappointment in half a season.