Two other starters, defensive tackle Ricky Jean Francois (foot) and cornerback Greg Toler (groin), have not returned from their injuries.
Indy's makeshift offensive line is a mess, too. Starting center Samson Satele (elbow) and starting right guard Jeff Linkenbach (quad) did not practice Wednesday. Joe Reitz, who replaced the injured Linkenbach against the Texans, also didn't practice because he was diagnosed with a concussion.
That's certainly not the ideal way to go into this game.
"I remember last year them having a great defense. They have a lot more wins this year," Luck said, recalling Indy's 20-13 road win over the two-win Chiefs. "They do a great job of creating tough plays for offenses (with) their defense."
In the last six quarters, Luck appears to have finally found a connection with his young receivers and it's resulted in six touchdown passes and just one interception over the last six quarters.
This week, it's the defense that has the bigger test.
Charles is coming off of an historic five-touchdown game, averages an impressive 4.8 yards, leads the AFC with 1,181 yards rushing and leads the league in total TDs (18). Alex Smith is fourth in the AFC in passer rating (91.0) and after losing three straight, the Chiefs have rebounded with back-to-back wins by a combined margin of 60 points.
"They run the ball very well. They do the little things right. That's a tribute to their head coach," Mathis said. "They make you pay if you're not bringing your A game."
All of which begs the question about which is tougher: Stopping Charles & Co. or proving they can finish the season with enough momentum to make a deep playoff run?
"I think it goes hand-in-hand," linebacker Jerrell Freeman said. "He (Charles) is definitely a Swiss army knife. He does it all, and he's definitely tough to stop, so it will be a great challenge for us."