Loyd also had a highlight-reel layup off a half-court pass from Lindsay Allen, and her three-point play with 12:05 left pushed the lead to 49-36.
Duke pulled within eight with just under 9 minutes left before Michaela Mabrey swished a deep 3-pointer that restored Notre Dame’s double-figure lead.
By that point, the Irish were well on their way to yet another double-digit win: 30 of their 31 victories were decided by at least 10 points.
They beat Florida State by 26 in the quarterfinals before their 35-point semifinal romp against No. 14 North Carolina State.
The Irish became the first school to go 19-0 through ACC regular-season and tournament play since Duke in 2001-02 and 2002-03.
That included three one-sided wins over the league’s preseason favorite, Duke.
Notre Dame won the previous two by a combined 32 points, including a 21-point drubbing on Feb. 2 that marked Duke’s first ACC loss at Cameron Indoor Stadium since 2008 and an 11-point defeat in South Bend two weeks earlier.