Goshen News, Goshen, IN

Community News Network

June 26, 2013

Novel vaccine fights Type 1 diabetes by stopping immune attack

(Continued)

NEW YORK —

Patients taking a 1-milligram dose of TOL-3021 had their C- peptide levels rise 20 percent, compared with a decline of 8.8 percent for patients on placebo, the researchers reported. Immune cells known as T cells that directly targeted the pancreatic beta cells were shown to decline in patients taking the drug, while other T cells weren't affected. The study turned up no serious side effects.

Steinman said a next step is to conduct a longer trial with more patients to determine how the drug works over a period as long as a year, and to pursue treatment of patients at different stages of the disease.

"We do want to look at treatment of children, and the ultimate would be to see if we can treat those at risk before they get the disease and do this in a preventive way," Steinman said. On the other end of the spectrum, "it could provide benefit, as we've seen here, to people who were diagnosed a few years ago as long as they have some islet cells to preserve."

Steinman and colleagues formed a company around the technology in April, called Tolerion Inc. They are looking at partnerships with pharmaceutical companies "and other vehicles for moving ahead," he said. The company may be able to use the platform in other autoimmune diseases in which the target of the errant immune response is known, such as Grave's disease, he said.

"The wind at our back is the good data we've seen in this trial," Steinman said.

Text Only
Community News Network
Parade
Magazine

Click HERE to read all your Parade favorites including Hollywood Wire, Celebrity interviews and photo galleries, Food recipes and cooking tips, Games and lots more.
AP Video
Traditional African Dishes Teach Healthy Eating The Carbon Trap: US Exports Global Warming 13 Struck by Lightning on Calif. Beach Baseball Hall of Famers Inducted Israel, Hamas Trade Fire Despite Truce in Gaza Italy's Nibali Set to Win First Tour De France Raw: Shipwrecked Concordia Completes Last Voyage Raw: Sea Turtle Hatchlings Emerge From Nest Raw: Massive Dust Storm Covers Phoenix 12-hour Cease-fire in Gaza Fighting Begins Raw: Bolivian Dancers Attempt to Break Record Raw: Israel, Palestine Supporters Rally in US Raw: Air Algerie Flight 5017 Wreckage Virginia Governor Tours Tornado Aftermath Judge Faces Heat Over Offer to Help Migrant Kids Kangaroo Goes Missing in Oklahoma More M17 Bodies Return, Sanctions on Russia Grow Raw: Deadly Tornado Hits Virginia Campground Ohio State Marching Band Chief Fired After Probe Raw: Big Rig Stuck in Illinois Swamp
Poll

With military action and tensions escalating between Russia and Ukraine, as well as Israel and Palestine, are you worried that the U.S. and other nations may get drawn into these conflicts?

Yes, it is a great concern of mine
I’m a little worried, but not too much
No, I’m not worried at all
     View Results